Convergent Solid‐Phase Synthesis of N‐Glycopeptides Facilitated by Pseudoprolines at Consensus‐Sequence Ser/Thr Residues

Remote control: The formation of aspartimides is greatly decreased during peptide elongation and during convergent sugar couplings of Asp-X-Ser/Thr peptides that contain a pseudoproline (red; see scheme). The robust approach efficiently joins complex peptides and N-glycans on the solid phase thus facilitating the availability of glycopeptides and glycoproteins.