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January 1, 1996Thrombosis and Haemostasis

A3 Domain Is Essential for Interaction of von Willebrand Factor with Collagen Type III

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Population

Baby hamster kidney cells overexpressing furin transfected with von Willebrand factor (vWF) deletion mutants

Comparison

vWF mutant lacking the A3 domain vs Wild-type vWF and vWF mutant lacking the A1 domain

Design

Preclinical

Authors

HLH. LankhofUtrecht UniversityMHMaggy van HoeijUtrecht UniversityMSMarion E. SchiphorstUtrecht University

Discussion

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Overview

A3 domain is essential for vWF-collagen binding and platelet adhesion; leaves open its value as a selective antithrombotic target pending human studies.

Structured PICO

P
Population
Baby hamster kidney cells overexpressing furin transfected with von Willebrand factor (vWF) deletion mutants
I
Intervention
vWF mutant lacking the A3 domain (residues 910-1113; delta A3-vWF)
C
Comparator
Wild-type vWF and vWF mutant lacking the A1 domain (residues 478-716; delta A1-vWF)
O
Outcome
Binding to collagen type III and support of platelet adhesion under flow conditionssurrogate

The A3 domain of von Willebrand factor contains the major collagen binding site and is essential for supporting platelet adhesion under flow conditions.

Cite This Study

Lankhof et al. (1996) studied this question.

synapsesocial.com/papers/6a8a87d76fc170cbc2fbf7ebhttps://doi.org/10.1055/s-0038-1650400
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of the glycoprotein Ib-binding A1 repeat and the RGD sequence in platelet adhesion to human recombinant von Willebrand factor1995 · 72 citations
  2. 2Localization of von Willebrand factor binding domains to endothelial extracellular matrix and to type VI collagen.1993 · 77 citations
  3. 3Isolation and characterization of a collagen binding domain in human von Willebrand factor.1986 · 107 citations
  4. 4Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease1994 · 52 citations
  5. 5Localization of a collagen-interactive domain of human von Willebrand factor between amino acid residues Gly 911 and Glu 1,3651987 · 60 citations