What question did this study set out to answer?

To characterize the clinical, radiologic, pathologic, and genetic features of primary pseudomyogenic hemangioendothelioma arising exclusively within bone.

February 12, 2016The American Journal of Surgical Pathology

Primary Pseudomyogenic Hemangioendothelioma of Bone

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To characterize the clinical, radiologic, pathologic, and genetic features of primary pseudomyogenic hemangioendothelioma arising exclusively within bone.
Evaluated clinicopathologic, radiologic, immunohistochemical, and genetic characteristics in a series of 10 patients (N=10; 9 male, 1 female; age range 12–74 y, mean 36.7 y) with primary osseous pseudomyogenic hemangioendothelioma.
All patients presented with multicentric, well-circumscribed lytic lesions located in the lower extremities (45%), spine and pelvis (25%), or upper extremities (15%), characterized histologically by spindled-to-epithelioid cells, reactive woven bone, and osteoclast-like giant cells.
Tumor cells were positive for keratin, ERG, and CD31 but negative for CD34, with the t(7;19)(q22;13) translocation confirmed in 3 cases.
No patients developed visceral dissemination during follow-up, though all showed stable or progressive osseous disease.

Structured PICO

Population

10 patients (9 male, 1 female) with primary pseudomyogenic hemangioendothelioma (PMH) of bone without soft tissue involvement, ages 12 to 74 years (mean 36.7 y).

Outcome

Clinicopathologic findings, morphology, immunohistochemistry, and clinical follow-up

Primary pseudomyogenic hemangioendothelioma exclusively involving bone is a rare, multicentric neoplasm with unusual morphology that can make accurate diagnosis challenging.

Limitations

limited follow-up

Discussion

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Implication

Alerts pathologists to diagnostic pitfalls in rare multicentric bone PMH; leaves open need for larger series on behavior.

Cite This Study

Inyang et al. (2016) studied this question.

synapsesocial.com/papers/6a8a890e755d28965dfd70c3 https://doi.org/10.1097/pas.0000000000000613

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Primary Pseudomyogenic Hemangioendothelioma of Bone

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Primary Pseudomyogenic Hemangioendothelioma of Bone

Key Points

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider