ESHE can clinically mimic dermatofibroma and should be considered in the differential diagnosis of skin nodules in young adults to avoid misdiagnosis as epithelioid sarcoma.
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Raises awareness of ESHE as a dermatofibroma mimic in young adults; extends the differential diagnosis literature while remaining hypothesis-generating.
Epithelioid sarcoma-like (pseudomyogenic) hemangioendothelioma (ESHE) represents a rare soft tissue and bone tumor that typically presents as nodule(s) in the distal extremities of young adults. The nodules traverse several tissue planes simultaneously and can involve the dermis, subcutis, skeletal muscle and bone. ESHE shares clinical and microscopic features with epithelioid sarcoma (ES), and, accordingly, is commonly misdiagnosed as ES. However, unlike ES, which has a poor prognosis, ESHE commonly follows an indolent course. Herein, we report a case of ESHE diagnosed by skin biopsy that clinically mimicked a dermatofibroma. We also provide clinical photographs of the lesions in various stages of development, representing information that has not been previously published, to our knowledge.
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Stuart et al. (2013) studied this question.
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