Key result
Routine biopsy of two periauricular erythematous papules in a 24-year-old woman led to the unexpected diagnosis of metastatic epithelioid hemangioendothelioma.
Why the study?
Extremely heterogeneous clinical presentation and disease progression complicates the diagnosis and management of epithelioid hemangioendothelioma.
Case Report (n=1)
Highlights the importance of routine biopsy for seemingly benign skin lesions to diagnose rare and potentially dangerous conditions like epithelioid hemangioendothelioma.
May prompt biopsy of atypical skin lesions; leaves open generalizability beyond this single case.
UNSTRUCTURED Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor with metastatic potential. EHE can have single- or multiorgan involvement, with presentations ranging from asymptomatic disease to pain and systemic symptoms. The extremely heterogeneous clinical presentation and disease progression complicates EHE diagnosis and management. We present the case of a 24-year-old woman with two periauricular erythematous papules, leading to the discovery of metastatic EHE through routine biopsy, despite a noncontributory medical history. Histology revealed the dermal proliferation of epithelioid cells and vacuoles containing red blood cells. Immunohistochemistry markers consistent with EHE solidified the diagnosis. Although extremely rare, prompt diagnosis of EHE is essential for informed decision-making and favorable outcomes. Key clinical and histopathological findings are highlighted to aid dermatologists in diagnosing and managing this uncommon condition.
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Pulsipher et al. (2023) conducted a case report in Epithelioid hemangioendothelioma (n=1). Routine biopsy was evaluated on Diagnosis of metastatic epithelioid hemangioendothelioma. Routine biopsy of two periauricular erythematous papules in a 24-year-old woman led to the unexpected diagnosis of metastatic epithelioid hemangioendothelioma.
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