Why the study?
Angiosarcomas share significant morphologic and immunohistochemical overlap with other sarcomas, making differential diagnosis challenging, especially in poorly differentiated tumors.
This review highlights the importance of combining traditional hematoxylin and eosin analysis with molecular studies for the accurate differential diagnosis of angiosarcomas.
H&E analysis remains essential for angiosarcoma diagnosis despite molecular overlap; leaves open integrated diagnostic algorithms in pathology practice.
Angiosarcomas (AS) represent a heterogenous group of tumors with variable clinical presentation. AS share an important morphologic and immunohistochemical overlap with other sarcomas, hence the differential diagnosis is challenging, especially in poorly-differentiated tumors. Although molecular studies provide significant clues, especially in the differential diagnosis with other vascular neoplasms, a thorough hematoxylin and eosin analysis remains an essential tool in AS diagnosis. In this review, we discuss pathological and molecular insights with emphasis on implications for differential diagnosis in cutaneous, breast, soft tissue and visceral AS.
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A 2021 study studied this question.
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