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May 18, 2013American Journal of Dermatopathology

Angiosarcoma

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Population

40 patients with angiosarcoma, including 9 metastatic, 23 localized, and 4 recurrent cases. Primary sites…

Design

Cohort

Authors

PRPriya RaoGLGuy LahatCAChristina A. Arnold

Discussion

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Overview

Endothelial marker panels may aid angiosarcoma diagnosis; leaves open any prognostic role.

Structured PICO

P
Population
40 patients with angiosarcoma (n=70 specimens on tissue microarray), including 9 metastatic, 23 localized, and 4 recurrent cases. Primary sites included breast, skin, soft tissue, heart (n=5), bone, and unknown.
I
Intervention
Immunohistochemical analysis of CD31, CD34, factor VIII, D2-40, and pan-cytokeratin
O
Outcome
Disease-specific survival (DSS)surrogate

Unusual patterns and loss of endothelial markers are common in angiosarcoma, suggesting the need for multiple markers in challenging cases, though they do not clearly predict disease-specific survival.

Cite This Study

Rao et al. (2013) studied this question.

synapsesocial.com/papers/6a8173aab3060df1303bf6bchttps://doi.org/10.1097/dad.0b013e318271295a
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Epithelioid Angiosarcoma of Deep Soft Tissue1991 · 287 citations
  2. 2Angiosarcoma of skin and soft tissue: A study of forty-four cases1981 · 545 citations
  3. 3Angiosarcoma of Soft Tissue1998 · 516 citations
  4. 4Localization of factor VIII-related antigen in vascular endothelial cells using an immunoperoxidase method1980 · 378 citations