What question did this study set out to answer?

To characterize the clinical, morphologic, and immunohistochemical profile of epithelioid angiosarcoma involving bone and soft tissue to improve diagnostic accuracy.

April 5, 2012Tumori

Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome.

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Population

7 patients with epithelioid angiosarcoma involving the bone (n = 4) and soft tissues (n = 3)

Design

Case_series

Authors

YCYunxin ChenBeijing Technology and Business University DSDanhua ShenPeking University KSKunkun SunPeking University

Discussion

Member takes

Implication

CD31 inclusion in IHC panels may aid epithelioid tumor diagnosis; case reports leave broader validation open.

Key Points

To characterize the clinical, morphologic, and immunohistochemical profile of epithelioid angiosarcoma involving bone and soft tissue to improve diagnostic accuracy.
Retrospective review of archival pathology records identified 7 cases of epithelioid angiosarcoma located in bone (n=4) and soft tissues (n=3).
Immunohistochemical evaluation tested tumor expression of markers including CD31, CD34, Factor VIII, cytokeratin, EMA, vimentin, desmin, and actin alongside clinical follow-up.
Tumors exhibited diffuse architecture with focal nesting mimicking metastatic carcinoma in 6 of 7 cases, which prompted initial misdiagnosis of carcinoma in 2 patients.
Immunohistochemical staining was positive for CD31 (7/7), vimentin (7/7), cytokeratin (6/7), CD34 (5/7), Factor VIII (4/7), EMA (2/7), and CD68 (3/7), but negative for desmin, actin, and CD45.
Clinical follow-up demonstrated aggressive behavior: 3 of 7 patients died of disease within 1 year, 2 developed local recurrence or metastases, and 2 remained disease-free.

Structured PICO

Population

7 patients with epithelioid angiosarcoma involving the bone (n = 4) and soft tissues (n = 3)

Intervention

Histopathologic and immunohistochemical analysis (including CD31, CD34, Factor VIII, cytokeratin, epithelial membrane antigen, vimentin, HMB45, CD1a, CD68, lysozyme, CD45, desmin, and smooth muscle actin)

Outcome

Clinical, histopathologic, and immunohistochemical findings, and clinical outcome

Endothelial markers such as CD31 should be included in immunohistochemical analysis of unusual epithelioid neoplasms to avoid misdiagnosing epithelioid angiosarcoma as metastatic carcinoma.

Cite This Study

Chen et al. (2012) studied this question.

synapsesocial.com/papers/6a8715a5a810ea404bcfa584 https://doi.org/10.1177/030089161109700508

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Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Epithelioid angiosarcoma of bone and soft tissue: a report of seven cases with emphasis on morphologic diversity, immunohistochemical features and clinical outcome.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider