Key result
A case of epithelioid angiosarcoma in a 57-year-old man highlights the importance of immunohistochemistry in differentiating these aggressive tumors from epithelial and melanocytic lesions.
Case Report (n=1)
Immunohistochemistry is crucial for differentiating epithelioid angiosarcoma from more common epithelial and melanocytic lesions.
Supports IHC in ambiguous vascular tumors; leaves open validation in larger cohorts before guideline changes.
Angiosarcomas are rare malignant tumors of endothelial cell origin comprising less than 1% of all sarcomas. Their morphologic features generally resemble dysplastic versions of normal vasculature. Epithelioid angiosarcoma is a variant of conventional angiosarcoma with little or no morphologic evidence of its vascular origin. These aggressive tumors are composed of malignant epithelioid cells growing in sheets with only focal vasoformative features. Immunohistochemistry is an important tool in differentiating these tumors from the more common epithelial and melanocytic lesions they resemble. We present a case of epithelioid angiosarcoma arising in deep soft tissue of the thigh in a 57-year-old man. A brief review of the literature is presented, and the differential diagnosis is discussed with particular emphasis placed on the issues facing the practicing pathologist.
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Branch et al. (2008) conducted a case report in Epithelioid angiosarcoma (n=1). A case of epithelioid angiosarcoma in a 57-year-old man highlights the importance of immunohistochemistry in differentiating these aggressive tumors from epithelial and melanocytic lesions.
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