Bone: Vascular Tumors

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Key Points

To review the clinical characteristics, classification spectrum, and underlying genetic alterations associated with vascular tumors of the bone.
Narrative synthesis of clinical features and molecular pathology across the spectrum of osseous vascular lesions.
Evaluation of benign, intermediate, and malignant categories alongside recently identified genetic mutations and translocations.
Vascular tumors of bone span a wide spectrum ranging from benign haemangiomas to intermediate epithelioid haemangiomas, low-grade malignant epithelioid hemangioendotheliomas, and frankly malignant angiosarcomas.
Distinct chromosomal translocations and specific recurrent gene mutations characterize particular subsets along this biological and clinical gradient.

P

Population

Patients with vascular tumors of bones

This review summarizes the clinical spectrum and genetic basis of vascular tumors of bone.

Updates bone vascular tumor classification; leaves open validation of genetic markers for clinical use.

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IJzendoorn et al. (2018) studied this question.

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