March 1, 1992Endocrinology

Regulation of insulin-like growth factor-binding proteins in serum and lymph of lactating cows by somatotropin.

View Full Paper

Ask AI

Bookmark

Population

4 lactating cows

Comparison

Bovine somatotropin 40 mg/day for 12-day periods vs Vehicle (cross-over design)

Design

Preclinical, cross-over design

Follow-up

12-day periods

Authors

WCWendie S. CohickRutgers, The State University of New Jersey MMMark A. McGuireElectrophysiology DCD R ClemmonsUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

bST modulates IGFBPs in lactating cows; leaves open translation to human GH-IGF physiology or therapy.

Structured PICO

Population

4 lactating cows

Intervention

Bovine somatotropin (bST) 40 mg/day for 12-day periods

Comparator

Vehicle (cross-over design)

Outcome

Levels of specific insulin-like growth factor-binding proteins (IGFBPs) in serum and afferent mammary lymphsurrogate

Bovine somatotropin administration in lactating cows differentially regulates IGF-binding proteins, increasing serum IGFBP-3 while decreasing IGFBP-2 in both serum and mammary lymph.

Cite This Study

Cohick et al. (1992) studied this question.

synapsesocial.com/papers/6a8a8bf54c30e1095aecbb86 https://doi.org/10.1210/endo.130.3.1371453

View Full Paper

Ask AI

Bookmark

Regulation of insulin-like growth factor-binding proteins in serum and lymph of lactating cows by somatotropin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of insulin-like growth factor-binding proteins in serum and lymph of lactating cows by somatotropin.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider