The effects of saikosaponins a, b 1 , b 2 , c and d, isolated from the root of Bupleurum falcatum L., on membrane fluidity using spin–labelled erythroeytes were examined. Saikosaponins a and b 2 in which the C–16 OH of epoxyoleanene skeleton is in β position caused the remarkable decrease of membrane fluidity but saikosaponin d and b 2 in which the 16 OH is in a position showed weaker actions on membrane fluidity. Key Word Index Bupleurum falcatum L - Saikosaponin - Spin–label - Membrane fluidity
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Abe et al. (1978) studied this question.