The PRISMA Extension for Network Meta-analysis: Bringing Clarity and Guidance to the Reporting of Systematic Reviews Incorporating Network Meta-analyses

Editorials2 June 2015The PRISMA Extension for Network Meta-analysis: Bringing Clarity and Guidance to the Reporting of Systematic Reviews Incorporating Network Meta-analysesJohn E. Cornell, PhDJohn E. Cornell, PhDFrom University of Texas Health Science Center at San Antonio, San Antonio, Texas.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-0930 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Systematic reviews that examine comparative effectiveness among competing interventions need to summarize evidence on the basis of indirect comparison of each intervention against a common comparator (placebo or usual care), along with direct evidence from a few studies that provide head-to-head comparisons. Network meta-analysis allows a flexible and powerful system to visualize and statistically combine indirect comparisons with evidence from direct comparisons across several competing interventions. The basic arithmetic underlying network meta-analysis is deceptively simple, but the essential assumptions that support its computational and conceptual validity are less easily understood outside the methodological community.The much-anticipated PRISMA (Preferred Reporting Items ...References1. Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. 2015;162:777-84. doi:10.7326/M14-2385 LinkGoogle Scholar2. Higgins JP, Whitehead A. Borrowing strength from external trials in a meta-analysis. Stat Med. 1996;15:2733-49. [PMID: 8981683] CrossrefMedlineGoogle Scholar3. Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G. Graphical tools for network meta-analysis in STATA. PLoS One. 2013;8:e76654. [PMID: 24098547] doi:10.1371/journal.pone.0076654 CrossrefMedlineGoogle Scholar4. Rochwerg B, Alhazzani W, Sindi A, Heels-Ansdell D, Thabane L, Fox-Robichaud A, et al; Fluids in Sepsis and Septic Shock Group. Fluid resuscitation in sepsis: a systematic review and network meta-analysis. Ann Intern Med. 2014;161:347-55. [PMID: 25047428] doi:10.7326/M14-0178 LinkGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of Texas Health Science Center at San Antonio, San Antonio, Texas.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-0930.Corresponding Author: John E. Cornell, PhD, Department of Epidemiology and Biostatistics, University of Texas Health Science Center at San Antonio, 7703 Merton Minter Boulevard, San Antonio, TX 78299; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations Brian Hutton , Georgia Salanti , Deborah M. Caldwell , Anna Chaimani , Christopher H. Schmid , Chris Cameron , John P.A. Ioannidis , Sharon Straus , Kristian Thorlund , Jeroen P. Jansen , Cynthia Mulrow , Ferrán Catalá-López , Peter C. Gøtzsche , Kay Dickersin , Isabelle Boutron , Douglas G. Altman , and David Moher The PRISMA Extension Statement for Reporting of Systematic Reviews Incorporating Network Meta-analyses of Health Care Interventions: Checklist and Explanations Brian Hutton , Georgia Salanti , Deborah M. Caldwell , Anna Chaimani , Christopher H. Schmid , Chris Cameron , John P.A. Ioannidis , Sharon Straus , Kristian Thorlund , Jeroen P. Jansen , Cynthia Mulrow , Ferrán Catalá-López , Peter C. Gøtzsche , Kay Dickersin , Isabelle Boutron , Douglas G. 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