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trigger epigenetically modifies asthma susceptibility genes, making this individual more prone to asthma development.In addition, identifying the epigenetic modifications resulting from coexposure of AECs to IL-13 combined with other stimuli such as cigarette smoke will be of importance, as aberrant DNA methylation has been detected in small airways of patients with chronic obstructive pulmonary disease (11).It will be interesting to see whether these new insights on DNA methylation and disease-specific gene expression changes can be further developed into novel diagnostic epigenetic markers, to see how they will contribute to unraveling disease mechanisms, and to assess their therapeutic implications.
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Oh et al. (2016) studied this question.
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