Why the study?
Can detailed phenotypic analysis using LTA and ATP secretion reliably diagnose and subclassify heritable platelet function disorders?
Population
111 unrelated research participants with suspected heritable platelet function disorders and 70 healthy…
Comparison
Lumi-aggregometry on 9 platelet agonists and… vs Healthy volunteers
Design
Cross-sectional
Authors
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Supports LTA/ATP testing in suspected PFDs; leaves open reliable subclassification of heritable disorders without prospective validation.
Can detailed phenotypic analysis using LTA and ATP secretion reliably diagnose and subclassify heritable platelet function disorders?
Detailed phenotypic analysis using LTA and ATP secretion with a streamlined panel of agonists is a powerful and reliable tool for diagnosing and subclassifying heritable platelet function disorders.
Dawood et al. (2012) studied this question.
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