THE exact standardization of desiccated thyroid is A difficult as it is not a pure chemical substance. Within U.S.P. specifications, thyroid-gland preparations vary in physiologic activity. A number of more purified compounds have been introduced to make the administration and standardization of thyroid medication more exact and therefore more predictable.1 Through the work of Harington,2 Kendall, Pitt Rivers, Hems and Clayton, pure L-thyroxine became available for general use.3 There has been general agreement about the equivalent dosage of desiccated thyroid and sodium levothyroxine needed for a similar clinical effect. Starr and Liebhold-Schueck4 considered that 0.1 mg. of sodium levothyroxine . . .
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Sturnick et al. (1961) studied this question.