Aplastic Anemia During the Treatment of Hyperthyroidism With Tapazole

Case Reports1 October 1954APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLEBENNETT LEVINE, M.D., DAVID V. ROSENBERG, M.D.BENNETT LEVINE, M.D.Search for more papers by this author, DAVID V. ROSENBERG, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-4-844 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince the introduction of thiouracil for the treatment of hyperthyroidism there has been a constant search for more potent and less toxic antithyroid drugs. None of these drugs, however, is free from a variety of undesirable toxic side effects. At the present time propylthiouracil and Tapazole (1-methyl-2-mercaptoimidazole) are the drugs most frequently employed because of their proved efficacy and the relatively low incidence of toxic side reactions. Toxic reactions of all types with propylthiouracil have occurred in 1.6 to 3.2 per cent of cases.1-4Severe leukopenia and agranulocytosis have occurred in 0.5 to 1.0 per cent of patients,2-9and several...Bibliography1. BellMishtowt GOGI: Use and abuse of thiouracil drugs, Am. J. Med. 10: 68-76, 1951. CrossrefMedlineGoogle Scholar2. Bartels EC: Agranulocytosis during propylthiouracil therapy, Am. J. Med. 5: 48-52, 1948. CrossrefMedlineGoogle Scholar3. McCullaghHibbsSchneider EPRERW: Propylthiouracil in treatment of hyperthyroidism, Am. J. M. Sc. 214: 545-552, 1947. CrossrefMedlineGoogle Scholar4. Bartels EC: Hyperthyroidism—an evaluation of treatment with antithyroid drugs followed by subtotal thyroidectomy, Ann. Int. Med. 37: 1123-1134, 1952. LinkGoogle Scholar5. LivingstonLivingston HJSF: Agranulocytosis and hepatocellular jaundice, toxic reactions following propylthiouracil therapy, J. A. M. A. 135: 422-425, 1947. CrossrefMedlineGoogle Scholar6. EisenmengerSteele WJMJ: Leukopenia following use of propylthiouracil, J. A. M. A. 135: 510-511, 1947. CrossrefMedlineGoogle Scholar7. BeebeProppMcClintockVarsaci RTSJCA: Fatal agranulocytosis during treatment of toxic goiter with propylthiouracil, Ann. Int. Med. 34: 1035-1040, 1951. LinkGoogle Scholar8. JuliarHarris BTL: Fatal agranulocytosis during propylthiouracil therapy, J. A. M. A. 139: 646-647, 1949. CrossrefMedlineGoogle Scholar9. ColwellSandoLang ARDESJ: Propylthiouracil-induced agranulocytosis, toxic hepatitis and death; report of a case, J. A. M. A. 148: 639-641, 1952. CrossrefMedlineGoogle Scholar10. HallmanBondy BLPK: Experience with methimazole (Tapazole) in the treatment of hyperthyroidism; a report of thirty-five cases, Am. J. Med. 11: 724-729, 1951. CrossrefMedlineGoogle Scholar11. CrokeBerry ARJW: Agranulocytosis occurring during methimazole ("tapazole") therapy; report of a case, J. A. M. A. 148: 45-46, 1952. CrossrefGoogle Scholar12. WilkinsClevelandKing RBFERL: Granulocytopenia from Tapazole; case report, Bull. Mason Clin. 5: 123-127, 1951. Google Scholar13. RosenbaumReveno HWS: Agranulocytosis and toxic hepatitis from methimazole, J. A. M. A. 152: 27, 1953. CrossrefMedlineGoogle Scholar14. WeisbergerHeinle ASRW: Study of fixed tissue sections of sternal bone marrow obtained by needle aspiration. II. Comparison of nucleated cell count and volumetric pattern with histologic appearance, Am. J. M. Sc. 215: 177, 1948. CrossrefMedlineGoogle Scholar15. ThierschConroyStevensFinch JBLARCJ: Adverse effect of cortisone on marrow regeneration following irradiation, J. Lab. and Clin. Med. 40: 174-192, 1952. MedlineGoogle Scholar16. LevineWeisberger BAS: Augmentation of nitrogen mustard induced leukopenia by cortisone, Proc. Soc. Exper. Biol. and Med. 82: 580-583, 1953. CrossrefMedlineGoogle Scholar17. CaldwellAdamsAndersonDick ALJWJFAA: Agranulocytosis treated with cortisone, Canad. M. A. J. 6: 506-507, 1950. Google Scholar18. Virkkunen M: Corticotropin and cortisone in the treatment of agranulocytosis and thrombocytopenic purpura, Arch. Int. Med. 90: 580-586, 1952. CrossrefGoogle Scholar19. McMillan JS: Successful use of ACTH in the treatment of agranulocytosis due to sulfadiazine, Am. J. M. Sc. 222: 396, 1951. MedlineGoogle Scholar20. Moore CV: In clinico-pathologic conference; aplastic anemia in a patient receiving chloramphenicol, Am. J. Med. 13: 782-792, 1952. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication February 26, 1954.From the Department of Medicine, University Hospitals, and the School of Medicine, Western Reserve University, Cleveland, Ohio. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThyroid hormone regulates hematopoiesis via the TR-KLF9 axisAplastic Anemia Associated with Antithyroid DrugsDrug-induced Aplastic Anaemia: Clinical AspectsThe role of eosinophils in granulopoiesis. I. Eosinophilia in neutropenic pateintsDEATH DURING THERAPEUTIC STARVATIONAPLASTIC ANÆMIA AFTER PROPYLTHIOURACILThe Relative Toxicity of Antithyroid DrugsRefractory anemias of pregnancyCortisone and its Analogues in Alimentary DisordersCortisone and its Analogues in HaematologyBONE MARROW DEPRESSION SUCCESSFULLY TREATED WITH HYDROCORTISONE AND CORTICOTROPIN (ACTH)*JOHN F. MURRAY, M.D., S. FRED RABINER, M.D., BERNARD KABAKOW, M.D.Thyreostatika 1 October 1954Volume 41, Issue 4Page: 844-848KeywordsAdverse reactionsAplastic anemiaDrugsHospital medicineHyperthyroidism ePublished: 1 December 2008 Issue Published: 1 October 1954 PDF downloadLoading ...