Fatal Agranulocytosis During Treatment of Toxic Goiter With Propylthiouracil

Case Reports1 April 1951FATAL AGRANULOCYTOSIS DURING TREATMENT OF TOXIC GOITER WITH PROPYLTHIOURACILRICHARD T. BEEBE, M.D., F.A.C.P., SIMON PROPP, M.D., JOHN C. MCCLINTOCK, M.D., ARMAND VERSACI, M.D.RICHARD T. BEEBE, M.D., F.A.C.P., SIMON PROPP, M.D., JOHN C. MCCLINTOCK, M.D., ARMAND VERSACI, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-34-4-1035 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe introduction of antithyroid drugs as therapeutic agents for the treatment of toxic goiter led to the belief that surgery would no longer be necessary to relieve hyperthyroidism. The accumulated experience of the past seven years has failed to support initial hopes and, in addition, has indicated certain hazards associated with the use of these drugs. Although new and less toxic forms of the original antithyroid agent have been developed, they cannot be used indiscriminately.A few carefully selected patients can obtain a cure of their hyperthyroidism from the judicious use of antithyroid agents alone. Many patients undergo thyroidectomy with...Bibliography1. AstwoodVanderlaan EBWP: Thiouracil derivatives of greater activity for the treatment of hyperthyroidism, J. Clin. Endocrinol. 5: 424-430, 1945. CrossrefGoogle Scholar2. AstwoodVanderlaan EBWP: Treatment of hyperthyroidism with propylthiouracil, Ann. Int. Med. 25: 813-821, 1946. LinkGoogle Scholar3. Bartels EC: Agranulocytosis during propylthiouracil therapy, Am. J. Med. 5: 48-52, 1948. CrossrefMedlineGoogle Scholar4. BeierwaltesSturgis WHCC: Thiouracil and propylthiouracil, J. Lab. and Clin. Med. 32: 392-396, 1947. MedlineGoogle Scholar5. Crile G: Practical aspects of thyroid disease, 1949, W. B. Saunders Co., Philadelphia, p. 90. Google Scholar6. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RICHARD T. BEEBE, M.D., F.A.C.P.; SIMON PROPP, M.D.; JOHN C. MCCLINTOCK, M.D.; ARMAND VERSACI, M.D.Affiliations: Albany, New York*Received for publication May 21, 1949.From the Departments of Medicine and Surgery, Albany Medical College and the Albany Hospital. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThionamidesIODINE AND DRUGS THAT AFFECT THYROID FUNCTIONThionamidesAgranulocytosis Associated with Antithyroid Drugs Effects of Patient Age and Drug DoseDAVID S. COOPER, M.D., DAVID GOLDMINZ, B.S., ANN A. LEVIN, M.S., PAUL W. LADENSON, M.D., GILBERT H. DANIELS, M.D., MARK E. MOLITCH, M.D., E. CHESTER RIDGWAY, M.D.Multiple complications of propylthiouracil treatment: granulocytopenia, eosinophilia, skin reaction and hepatitis with lymphocyte sensitizationThe Pharmacotherapy of Thyroid StormThe Relative Toxicity of Antithyroid DrugsVALUE OF AMINOPYRINE*†LEONARD CARDON, M.D., F.A.C.P., OSCAR H. COMESS, M.D., THOMAS A. NOBLE, M.D., MARK M. POMARANC, M.D.APLASTIC ANEMIA DURING THE TREATMENT OF HYPERTHYROIDISM WITH TAPAZOLE*BENNETT LEVINE, M.D., DAVID V. ROSENBERG, M.D.Fulminant Hepatitis during Treatment with PropylthiouracilAllergy to Drugs 1 April 1951Volume 34, Issue 4Page: 1035-1040KeywordsDrug therapyDrugsHospital medicineHyperthyroidismSurgeryThyroidectomy ePublished: 1 December 2008 Issue Published: 1 April 1951 PDF downloadLoading ...