Why the study?
The potential pharmacological mechanisms of Ganshuang granules in treating non-alcoholic fatty liver disease were not well defined.
Do Ganshuang granules improve liver enzymes, lipid profiles, and inflammatory markers in diet-induced mouse models of NAFLD?
Population
Diet-induced mouse models of NAFLD
Comparison
GSG treatment vs untreated controls
Design
Network pharmacology and animal experimental study
Authors
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Predicted GSG targets in NAFLD are hypothesis-generating; leaves open need for experimental and clinical validation.
Do Ganshuang granules improve liver enzymes, lipid profiles, and inflammatory markers in diet-induced mouse models of NAFLD?
Ganshuang granules improve liver enzymes, lipid profiles, and inflammation in a mouse model of NAFLD, potentially by modulating the PI3K/AKT signaling pathway.
Guoguo et al. (2024) studied this question.
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