A variety of regioisomeric bifunctionalized β-cyclodextrins derivatized with an imidazole and a metal ligand tris(2-aminoethyl)amine (tren) group were prepared. As their Zn2+ complexes, these compounds show bifunctional catalysis of phosphate hydrolysis with a regioisomeric preference.
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Dong et al. (1998) studied this question.
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