March 1, 1975American Journal of Physiology-Legacy Content
Fate of labeled angiotensin II microinfused into individual nephrons in the rat
Population
Inactin-anesthetized rats (individual nephrons)
Comparison
Microinfusion of 14C-labeled angiotensin II and… vs Comparison between proximal and distal tubule…
Design
Preclinical
Authors
Discussion
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Implication
Supports proximal tubular angiotensin II cleavage in rats; leaves open human relevance and therapeutic implications.
Structured PICO
P
Population
Inactin-anesthetized rats (individual nephrons)
I
Intervention
Microinfusion of 14C-labeled angiotensin II ([14C]AII) and tritiated inulin ([3H]In) into proximal or distal tubules
C
Comparator
Comparison between proximal and distal tubule infusion sites
O
Outcome
Urinary excretion and recovery of 14C and its metabolitessurrogate
Rapid removal of angiotensin II by proximal tubular cells occurs by enzymatic cleavage at the luminal surface, with reabsorption of most products.
Cite This Study
Pullman et al. (1975) studied this question.