What question did this study set out to answer?

To evaluate the performance of genome-wide association study-identified common genetic variants in predicting breast cancer risk among women of East Asian ancestry.

December 1, 2016Breast Cancer ResearchOpen Access

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

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Authors

WWWanqing WenVanderbilt University XSXiao‐Ou ShuChongqing University XGXingyi GuoVanderbilt University Medical Center

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Implication

Case-control study reveals polygenic risk scores stratify breast cancer risk in East Asian women, indicating utility for targeted screening.

Key Points

To evaluate the performance of genome-wide association study-identified common genetic variants in predicting breast cancer risk among women of East Asian ancestry.
Analyzed 88 previously reported breast cancer risk variants in 11,760 cases and 11,612 controls of Asian ancestry.
Constructed a polygenic risk score (PRS) using single-nucleotide polymorphisms confirmed to be associated with breast cancer risk.
Estimated relative and absolute breast cancer risks across PRS percentiles to stratify individuals into risk categories.
Confirmed significant associations with breast cancer risk for single-nucleotide polymorphisms in 44 of 78 loci (P < 0.05).
Compared to the middle quintile, women in the top 1% of the PRS had a 2.70-fold higher risk of breast cancer (95% CI: 2.15–3.40), yielding a model AUC of 0.606.
Estimated lifetime breast cancer risk for Shanghai Chinese women ranged from 1.35% in the lowest 1% of the PRS to 10.06% in the highest 1%.

Cite This Study

Wen et al. (2016) studied this question.

synapsesocial.com/papers/6a8a98a7fe45b30291c14a05 https://doi.org/10.1186/s13058-016-0786-1

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Implication

Case-control study reveals polygenic risk scores stratify breast cancer risk in East Asian women, indicating utility for targeted screening.

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

Discussion

Member takes

Implication

Key Points

Cite This Study

Prediction of breast cancer risk based on common genetic variants in women of East Asian ancestry

Discussion

Member takes

Implication

Key Points

Cite This Study

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