Why the study?
Does paralyzing the renin-angiotensin system retard the progression of diabetic nephropathy?
Does paralyzing the renin-angiotensin system retard the progression of diabetic nephropathy?
This review discusses the role of renin-angiotensin system inhibition in retarding the progression of diabetic nephropathy.
High historical mortality in diabetic nephropathy warrants evaluation of renin-angiotensin inhibition; leaves open its effect on progression in contemporary cohorts.
In the early 1980s, patients with diabetic nephropathy (DN) had a doomed prognosis. Severe renal failure developed within five years of the onset of proteinuria.[1] The mortality was 53%, with 59% of deaths attributable to renal failure. There is no doubt that this devastating complication of diabetes has caused immeasurable human suffering and enormous healthcare costs.
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Muhammad Asim (2005) studied this question.
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