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October 1, 1994Journal of Clinical Pharmacy and TherapeuticsOpen Access

Therapeutic progress III: Diabetic nephropathy

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Why the study?

Does angiotensin converting enzyme inhibitors prevent progression of deterioration in renal function in patients with diabetic nephropathy?

Population

Patients with diabetic nephropathy (in the presence or absence of hypertension)

Design

Review

Authors

SMS. R. J. MaxwellUniversity of EdinburghNGNeil GittoesQueen Elizabeth Hospital Birmingham

Discussion

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Overview

Supports early ACE inhibitor use at microalbuminuria in diabetes; leaves open need for updated RCTs with contemporary therapies.

Structured PICO

Does angiotensin converting enzyme inhibitors prevent progression of deterioration in renal function in patients with diabetic nephropathy?

P
Population
Patients with diabetic nephropathy (in the presence or absence of hypertension)
I
Intervention
Angiotensin converting enzyme (ACE) inhibitors
O
Outcome
Progression of deterioration in renal functionsurrogate

ACE inhibitors provide specific renal protection in diabetic nephropathy, slowing or potentially arresting disease progression when initiated early.

Cite This Study

Maxwell et al. (1994) studied this question.

synapsesocial.com/papers/6a7e313a971946435f4f97dchttps://doi.org/10.1111/j.1365-2710.1994.tb00815.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients1993 · 784 citations
  2. 2Efficacy of captopril in postponing nephropathy in normotensive insulin dependent diabetic patients with microalbuminuria.1991 · 469 citations
  3. 3Effect of Captopril on Heavy Proteinuria in Azotemic Diabetics1985 · 419 citations
  4. 4Microalbuminuria: A Major Risk Factor in Non‐insulin‐dependent Diabetes. A 10‐year Follow‐up Study of 503 Patients1988 · 443 citations
  5. 5Prevention of diabetic nephropathy with enalapril in normotensive diabetics with microalbuminuria.1988 · 384 citations