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August 1, 1995Journal of Hypertension

Effects of angiotensin converting enzyme inhibitors on the progression of diabetic nephropathy

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Why the study?

Do ACE inhibitors prevent the progression of renal failure and development of macroalbuminuria in patients with diabetes mellitus?

Population

Patients with diabetes mellitus

Design

Review

Authors

LRLuís M. Ruilope

Discussion

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Overview

Supports ACE inhibitor preference in diabetic nephropathy; extends prior data but hypothesis-generating pending prospective trials.

Structured PICO

Do ACE inhibitors prevent the progression of renal failure and development of macroalbuminuria in patients with diabetes mellitus?

P
Population
Patients with diabetes mellitus
I
Intervention
Angiotensin converting enzyme (ACE) inhibitors
O
Outcome
Progression of renal failure and development of macroalbuminuriasurrogate

ACE inhibitors provide renoprotective benefits beyond blood pressure lowering and are considered the drugs of choice in diabetic patients with hypertension or renal dysfunction.

Cite This Study

Luís M. Ruilope (1995) studied this question.

synapsesocial.com/papers/6a89883d65c8981d3ff7c40ahttps://doi.org/10.1097/00004872-199508001-00015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Section Review: Cardiovascular & Renal: Angiotensin converting enzyme inhibitors and nephroprotection1995
  2. 2Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease1997 · 429 citations
  3. 3Therapeutic progress III: Diabetic nephropathy1994 · 1 citations
  4. 4Renal protection and angiotensin converting enzyme inhibition in microalbuminuric type I and type II diabetic patients1996 · 27 citations
  5. 5Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease2001 · 1,115 citations