November 1, 1995Expert Opinion on Investigational Drugs
Section Review: Cardiovascular & Renal: Angiotensin converting enzyme inhibitors and nephroprotection
Why the study?
Do ACE inhibitors reduce proteinuria and slow the progression of renal disease in patients with diabetic and non-diabetic renal failure compared to other antihypertensive drugs?
Population
Patients with diabetic nephropathy and chronic renal failure of non-diabetic origin, including normotensive…
Comparison
Angiotensin converting enzyme (ACE) inhibitors vs Other antihypertensive drugs
Design
Review
Authors
Discussion
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Member takes
Implication
May support ACE inhibitor preference for nephroprotection beyond BP control; leaves open confirmatory RCTs in normotensive patients.
Structured PICO
Do ACE inhibitors reduce proteinuria and slow the progression of renal disease in patients with diabetic and non-diabetic renal failure compared to other antihypertensive drugs?
P
Population
Patients with diabetic nephropathy and chronic renal failure of non-diabetic origin, including normotensive patients, as well as animal models of glomerulosclerosis.
I
Intervention
Angiotensin converting enzyme (ACE) inhibitors
C
Comparator
Other antihypertensive drugs
O
Outcome
Proteinuria and progression of renal disease
ACE inhibitors are the treatment of choice for nephroprotection in both diabetic and non-diabetic chronic renal failure, even in normotensive patients.
Cite This Study
Franek et al. (1995) studied this question.