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October 1, 2000American Journal of Health-System Pharmacy

Role of angiotensin-converting-enzyme inhibition in patients with renal disease

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Why the study?

Does ACE inhibitor therapy prevent the progression of renal disease in patients with diabetes or hypertension?

Population

Patients likely to develop renal disease, specifically those with diabetes or hypertension

Comparison

Angiotensin-converting-enzyme inhibitor therapy vs Placebo

Design

Review

Authors

HMHarold J. ManleyUniversity of Minnesota

Discussion

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Implication

Supports ACE inhibitor preference in diabetic nephropathy; confirms renoprotective effects beyond BP reduction in reviewed evidence.

Structured PICO

Does ACE inhibitor therapy prevent the progression of renal disease in patients with diabetes or hypertension?

P
Population
Patients likely to develop renal disease, specifically those with diabetes or hypertension
I
Intervention
Angiotensin-converting-enzyme (ACE) inhibitor therapy (including captopril, enalapril, lisinopril, and ramipril)
C
Comparator
Placebo
O
Outcome
Progression of renal disease (including death, dialysis, transplantation, serum creatinine changes, and development of overt nephropathy)

This review highlights that ACE inhibitors provide significant renoprotective benefits independent of blood pressure lowering in patients with diabetes or hypertension.

Cite This Study

Harold J. Manley (2000) studied this question.

synapsesocial.com/papers/6a8232abe35fc7ca402a52c0https://doi.org/10.1093/ajhp/57.suppl_1.s12

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin-Converting Enzyme Inhibitors and Renal Function1990 · 34 citations
  2. 2Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease2001 · 1,116 citations
  3. 3Section Review: Cardiovascular & Renal: Angiotensin converting enzyme inhibitors and nephroprotection1995
  4. 4Angiotensin-Converting Enzyme Inhibition and Renal Protection in Nondiabetic Patients2005 · 93 citations
  5. 5Angiotensin Converting Enzyme Inhibitors and Progressive Renal Insufficiency1989 · 158 citations