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June 15, 1998Annals of Internal Medicine

Use of Enalapril To Attenuate Decline in Renal Function in Normotensive, Normoalbuminuric Patients with Type 2 Diabetes Mellitus

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Why the study?

Does enalapril attenuate the decline in renal function and reduce albuminuria in normotensive, normoalbuminuric patients with type 2 diabetes?

Population

156 normotensive, normoalbuminuric patients with type 2 diabetes diagnosed after 40 years of age

Comparison

Enalapril 10 mg/d vs Placebo

Design

RCT, Randomized, double-blind

Follow-up

6 years

Authors

MRMordchai RavidBen-Gurion University of the Negev

Discussion

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Overview

Supports early enalapril use to prevent microalbuminuria in normotensive type 2 diabetes; extends renoprotective evidence to this population.

Structured PICO

Does enalapril attenuate the decline in renal function and reduce albuminuria in normotensive, normoalbuminuric patients with type 2 diabetes?

P
Population
156 normotensive (baseline mean blood pressure < 107 mm Hg), normoalbuminuric (albumin excretion <= 30 mg/24 h) patients with type 2 diabetes diagnosed after 40 years of age
I
Intervention
Enalapril 10 mg/d
C
Comparator
Placebo
O
Outcome
Degree of albuminuria at 24 hours and creatinine clearancesurrogate

Enalapril attenuates the decline in renal function and reduces the development of microalbuminuria in normotensive, normoalbuminuric patients with type 2 diabetes.

Cite This Study

Mordchai Ravid (1998) studied this question.

synapsesocial.com/papers/6a7ce2d3413d908bbb8d19afhttps://doi.org/10.7326/0003-4819-128-12_part_1-199806150-00004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renal protective effect of enalapril in diabetic nephropathy.1992 · 440 citations
  2. 2Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study1996 · 445 citations
  3. 3Effect of Antihypertensive Therapy on the Kidney in Patients with Diabetes: A Meta-Regression Analysis1993 · 600 citations
  4. 4Predicting Diabetic Nephropathy in Insulin-Dependent Patients1984 · 1,583 citations
  5. 5Microalbuminuria: A Major Risk Factor in Non‐insulin‐dependent Diabetes. A 10‐year Follow‐up Study of 503 Patients1988 · 443 citations