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April 15, 1993Annals of Internal Medicine

Long-Term Stabilizing Effect of Angiotensin-Converting Enzyme Inhibition on Plasma Creatinine and on Proteinuria in Normotensive Type II Diabetic Patients

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Why the study?

Does enalapril prevent the progression of proteinuria and decline in kidney function in normotensive type II diabetic patients with microalbuminuria?

Population

94 normotensive, type II diabetic patients with microalbuminuria and normal renal function.

Comparison

Enalapril 10 mg per day for 5 years. vs Matching placebo for 5 years. Both groups…

Design

RCT, Randomly assigned, double-blind, placebo-controlled

Follow-up

5 years

Authors

MRMordchai RavidBen-Gurion University of the Negev

Discussion

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Overview

Supports enalapril initiation for renal preservation in normotensive type 2 diabetes with microalbuminuria; extends renoprotection evidence beyond blood pressure effects.

Structured PICO

Does enalapril prevent the progression of proteinuria and decline in kidney function in normotensive type II diabetic patients with microalbuminuria?

P
Population
94 normotensive, type II diabetic patients with microalbuminuria and normal renal function.
I
Intervention
Enalapril 10 mg per day for 5 years.
C
Comparator
Matching placebo for 5 years. Both groups received long-acting nifedipine for any increase in blood pressure.
O
Outcome
Proteinuria (albuminuria) and rate of decline in kidney function (plasma creatinine) over 5 years.surrogate

Enalapril provides long-term stabilization of kidney function and proteinuria in normotensive patients with type II diabetes and microalbuminuria, independent of its antihypertensive effect.

Cite This Study

Mordchai Ravid (1993) studied this question.

synapsesocial.com/papers/6a7d57f358b935a3e446dcdchttps://doi.org/10.7326/0003-4819-118-8-199304150-00001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of Enalapril To Attenuate Decline in Renal Function in Normotensive, Normoalbuminuric Patients with Type 2 Diabetes Mellitus1998 · 388 citations
  2. 2Effects of Long-term Enalapril Treatment on Persistent Microalbuminuria in Normotensive Type 2 Diabetic Patients: Results of a 4-year, Prospective, Randomized Study1996 · 77 citations
  3. 3Long-term Renoprotective Effect of Angiotensin-converting Enzyme Inhibition in Non—insulin-dependent Diabetes Mellitus1996 · 316 citations
  4. 4Long-term renoprotective effect of angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. A 7-year follow-up study1996 · 445 citations
  5. 5Angiotensin converting enzyme inhibition in normotensive type II diabetics with persistent mild proteinuria1989 · 25 citations