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July 17, 2001Annals of Internal Medicine

Angiotensin-Converting Enzyme Inhibitors and Progression of Nondiabetic Renal Disease

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Why the study?

Do antihypertensive regimens including ACE inhibitors reduce the progression to end-stage renal disease in patients with nondiabetic renal disease?

Population

1,860 nondiabetic patients with predominantly nondiabetic renal disease pooled from 11 randomized…

Comparison

Antihypertensive regimens including ACE inhibitors vs Antihypertensive regimens without ACE inhibitors

Design

Meta-analysis

Follow-up

mean 2.2 years

Authors

TJTazeen H. Jafar

Discussion

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Overview

Supports ACE inhibitor regimens in nondiabetic CKD; confirms renal protection in Level 1 meta-analysis.

Structured PICO

Do antihypertensive regimens including ACE inhibitors reduce the progression to end-stage renal disease in patients with nondiabetic renal disease?

P
Population
1,860 nondiabetic patients with predominantly nondiabetic renal disease pooled from 11 randomized, controlled trials.
I
Intervention
Antihypertensive regimens including ACE inhibitors
C
Comparator
Antihypertensive regimens without ACE inhibitors
O
Outcome
End-stage renal disease and the combined outcome of doubling of the baseline serum creatinine concentration or end-stage renal diseasehard clinical

Antihypertensive regimens containing ACE inhibitors significantly slow the progression of nondiabetic renal disease, with greater benefits observed in patients with higher baseline proteinuria.

Limitations

  • Data were inconclusive as to whether the benefit extended to patients with baseline urinary protein excretion less than 0.5 g/d

Cite This Study

Tazeen H. Jafar (2001) studied this question.

synapsesocial.com/papers/6a7cfac8e7e9b6b0df2fa878https://doi.org/10.7326/0003-4819-135-2-200107170-00007
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Angiotensin-Converting Enzyme Inhibitors on the Progression of Nondiabetic Renal Disease1997 · 429 citations
  2. 2Angiotensin Converting Enzyme Inhibitors and Progressive Renal Insufficiency1989 · 158 citations
  3. 3Review: angiotensin-converting enzyme inhibitors reduce the progression of non-diabetic renal disease2002 · 4 citations
  4. 4Angiotensin-Converting Enzyme Inhibition and Renal Protection in Nondiabetic Patients2005 · 93 citations
  5. 5Angiotensin-converting enzyme inhibitors and progression of nondiabetic chronic renal disease1993 · 31 citations