Why the study?
Does DL-DOPS improve blood pressure response to orthostatic challenge in patients with neurogenic orthostatic hypotension?
Population
10 patients with neurogenic orthostatic hypotension (central and peripheral autonomic nervous system disease)
Comparison
3,4-DL-threo-dihydroxyphenylserine (DL-DOPS) vs Placebo
Design
RCT, randomized, crossover, double-blind
Authors
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Supports DL-DOPS for neurogenic orthostatic hypotension; confirms norepinephrine precursor efficacy in RCT.
Does DL-DOPS improve blood pressure response to orthostatic challenge in patients with neurogenic orthostatic hypotension?
DL-DOPS effectively increases blood pressure and improves symptoms in patients with neurogenic orthostatic hypotension by increasing plasma norepinephrine levels.
Freeman et al. (1999) studied this question.
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