Methotrexate and Misoprostol against Misoprostol Alone for Early Medical Abortion: Comparative Study

Background: Vaginal mifepristone oral misoprostol have proven to be highly effective medicalabortion methods and are used widely in in modern countries.Objectives: The objective of this study is to compare the efficacy for two medical abortion regimensused in one clinic setting misoprostol alone, intramuscular methotrexate and vaginal misoprostol.Methods: An intervention study was conducted on a total of 100 randomly selected women withgestations of first-trimester pregnancy, who sought a missed abortion. Study population was assignedas two groups, the first was subjected to vaginal administration of Misoprostol and the second wassubjected to IM injection of methotrexate and self-administration of vaginal misoprostol After 72h.All patients were followed up for recording any side effects of the drugs, progress of abortion & ifthere was any need for surgical interference [manual vacuum aspiration (MVA) or dilatation andcurettageResults: Success rate of the methotrexate regimen was 80% and did not differ significantly from themisoprostol regimen that had success rate of 84%.Conclusions: In this real-use setting, the use of misoprostol in combination with methotrexate oralone for the missed abortion termination are both safe and effective methods without serious sideeffects.