March 1, 1985Cardiovascular Research
Influence of -adrenergic blockade on platelet-mediated thrombosis in stenosed canine coronary arteries
Why the study?
Does alpha-adrenergic blockade prevent platelet-mediated thrombosis in stenosed canine coronary arteries?
Population
46 open-chest dogs with a critical coronary stenosis produced by plicating the coronary artery wall with a…
Comparison
Phentolamine, prazosin, yohimbine, or prazosin +… vs Control (no intervention, n=9)
Design
Preclinical
Follow-up
1 hour
Authors
Discussion
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Overview
Alpha blockade ineffective in canine coronary thrombosis model; leaves open phentolamine's independent platelet inhibition for translational study.
Structured PICO
Does alpha-adrenergic blockade prevent platelet-mediated thrombosis in stenosed canine coronary arteries?
P
Population
46 open-chest dogs with a critical coronary stenosis produced by plicating the coronary artery wall with a suture
I
Intervention
Phentolamine (low dose: 0.07 mg/kg bolus followed by 0.1 mg/kg/min, or high dose: 3 mg/kg bolus followed by 0.07 mg/kg/min), prazosin (2 mg/kg), yohimbine (3 mg/kg), or prazosin + yohimbine
C
Comparator
Control (no intervention, n=9)
O
Outcome
Cyclical reductions in coronary blood flowsurrogate
Alpha-adrenoceptors do not contribute significantly to spontaneous formation of platelet coronary thrombi in a canine model, and phentolamine exhibits platelet-inhibitory activity independent of alpha-blockade.
Cite This Study
Bolli et al. (1985) studied this question.