Population
In vitro vertebrate smooth muscle and nonmuscle myosin II, and COS-7 cells expressing green fluorescent…
Comparison
Deletion of the 28 residues at the C-terminal… vs Wild type myosin, myosin with nonhelical tail…
Design
Preclinical
Authors
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Identifies essential residues for myosin II filament formation in animal models; leaves open whether this domain can be targeted in human disease.
The 28 residues at the C-terminal end of the coiled-coil domain are essential for the filament formation of smooth muscle and nonmuscle myosin II.
Ikebe et al. (2001) studied this question.
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