July 1, 1986Journal of Neurochemistry

Regulation of the Actin‐Activated Mg‐ATPase of Brain Myosin via Phosphorylation by the Brain Ca2+, Calmodulin‐Dependent Protein Kinases

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Population

Rat brain-derived Ca2+, calmodulin-dependent protein kinases (120K and 640K enzymes) and brain myosin

Comparison

Phosphorylation by 120K and 640K Ca2+… vs Chicken gizzard myosin light-chain kinase

Design

Preclinical

Authors

ETEtsuro TanakaTokyo University of Agriculture KFKohji FukunagaTohoku University HYHideyuki YamamotoUniversity of Fukui

Discussion

Member takes

Implication

Distinguishes brain from smooth muscle myosin regulation; leaves open translation to human cardiovascular or neurological conditions.

Structured PICO

Population

Rat brain-derived Ca2+, calmodulin-dependent protein kinases (120K and 640K enzymes) and brain myosin

Intervention

Phosphorylation by 120K and 640K Ca2+, calmodulin-dependent protein kinases

Comparator

Chicken gizzard myosin light-chain kinase

Outcome

Actin-activated Mg-ATPase activity and phosphorylation of myosin light and heavy chainssurrogate

Brain myosin is regulated by brain Ca2+, calmodulin-dependent protein kinases through a mechanism similar but distinct from smooth muscle myosin, increasing actin-activated Mg-ATPase activity.

Cite This Study

Tanaka et al. (1986) studied this question.

synapsesocial.com/papers/6a8aa0246fc170cbc2fc0282 https://doi.org/10.1111/j.1471-4159.1986.tb02857.x

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Regulation of the Actin‐Activated Mg‐ATPase of Brain Myosin via Phosphorylation by the Brain Ca2+, Calmodulin‐Dependent Protein Kinases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Regulation of the Actin‐Activated Mg‐ATPase of Brain Myosin via Phosphorylation by the Brain Ca2+, Calmodulin‐Dependent Protein Kinases

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider