Why the study?
Do gentamicin and negamycin induce readthrough of premature stop codons and restore laminin alpha2-chain protein expression in LAMA2-mutated myotubes?
Do gentamicin and negamycin induce readthrough of premature stop codons and restore laminin alpha2-chain protein expression in LAMA2-mutated myotubes?
While gentamicin and negamycin can induce readthrough of premature stop codons and stabilize mRNA in LAMA2-mutated myotubes, they fail to restore functional laminin alpha2-chain protein expression.
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Neither restores laminin alpha2-chain despite readthrough in patient myotubes; leaves open whether alternative strategies can achieve functional re-expression.
Allamand et al. (2007) studied this question.
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