Population
In vitro model coexpressing myosin Ibeta heavy chain with calmodulin mutants
Comparison
Calmodulin mutants (E12Q, E34Q, E1234Q) vs Wild-type calmodulin
Design
Preclinical
Authors
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C-terminal calmodulin Ca2+-binding sites are critical for myosin Ibeta regulation; leaves open relevance to cardiac myosins.
The C-terminal pair of Ca2+-binding sites on calmodulin are critical for the regulation of unconventional myosins by Ca2+.
Zhu et al. (1998) studied this question.
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