Dynamic One‐Pot Three‐Component Catalytic Asymmetric Transformation by Combination of Hydrogen‐Bond‐Donating and Amine Catalysts

In control: The first dynamic one-pot three-component asymmetric transformation between aldehydes, protected α-cyanoglycine esters, and enals catalyzed by a combination of a simple hydrogen-bond-donating catalyst and a chiral amine catalyst is disclosed. Polysubstituted proline derivatives, which have a quaternary α stereocenter, were synthesized with high endo-, diastereo-, and enantioselectivities (93–99 % ee).