Population
Control and streptozotocin-induced diabetic rats
Comparison
Alpha-tocopherol treatment, and administration… vs Untreated diabetic rats and control rats
Design
Preclinical
Authors
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May warrant preclinical follow-up on arginine in diabetic kidney disease; leaves open human translation.
In diabetic rats, reduced renomedullary NO and oxygen tension are driven by decreased plasma arginine from increased hepatic degradation, which can be restored by arginine or antioxidants.
Palm et al. (2007) studied this question.
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