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September 16, 2003Blood

Neonatal gene transfer with a retroviral vector results in tolerance to human factor IX in mice and dogs

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Authors

JZJun ZhangHebei Agricultural UniversityLXLingfei XuWashington University in St. LouisMHMark E. HaskinsAstraZeneca (Netherlands)

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Zhang et al. (2003) studied this question.

synapsesocial.com/papers/6a8aa2e11fb56efa37d4b369https://doi.org/10.1182/blood-2003-06-2181
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neonatal or hepatocyte growth factor–potentiated adult gene therapy with a retroviral vector results in therapeutic levels of canine factor IX for hemophilia B2003 · 102 citations
  2. 2Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy2002 · 340 citations
  3. 3Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII1993 · 266 citations
  4. 4Hematology: Basic Principles and Practice1991 · 1,865 citations
  5. 5Isolation and characterization of a cDNA coding for human factor IX.1982 · 420 citations