Population
Human platelets (in vitro model)
Design
Preclinical
Authors
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Identifies candidate PAR4 antagonists for testing; leaves open translation to clinical antithrombotic efficacy.
The study describes the synthesis of novel indole-based PAR4 antagonists and a high-throughput screening assay, identifying new scaffolds for potential antithrombotic drug development.
Young et al. (2013) studied this question.
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