The interaction between glucose levels and body mass index on the regulation of the circulating sphingolipidome in humans

Camillo Morano; Lucia Centofanti; Michele Dei; Riccardo Zanzi; Giuseppe De Pinto; B. Monica; Paola Zermiani; Elena Bianco; Federica Samartin; Sara Penati; Ilaria Pes; Ilaria Goggi; Pamela Senesi; Graziano Serrao; Loredana Bucciarelli; Francesca Bravi; Antonio Russo; Marco Trinchera; Pier Maria Battezzati; Monica Ferraroni; Franco Folli; Rita Paroni

doi:10.1152/ajpendo.00049.2026

Key Points

To examine how circulating sphingolipid profiles are altered by the interaction between glucose concentrations and body mass index in humans.
Analyzed circulating sphingolipid species across individuals stratified by glycemic status (impaired fasting glucose and diabetes) and body mass index categories.
Assessed specific enzymatic sphingolipid classes, including hexosylceramides, lactosylceramides, and dihydroceramides, across sex and metabolic subgroups.
Hexosylceramides and lactosylceramides unexpectedly decreased in individuals with impaired fasting glucose and diabetes, both with and without obesity.
Dihydroceramides increased in overweight and obese individuals with prediabetes or diabetes.
The circulating sphingolipidome demonstrated differential regulation influenced by sex, glucose levels, and body mass index.

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Implication

Reveals distinct shifts in circulating ceramides linked to glucose levels and body mass index, indicating differential metabolic regulation of the sphingolipidome.

Abstract

Sphingolipid glycosylation is an enzymatic process that does not follow the pattern of nonenzymatic hemoglobin glycosylation. Unexpectedly, hexosyl- and lactosylceramides decreased in impaired fasting glucose and diabetes, with and without obesity. On the other hand, dihydroceramides increased in overweight/obesity with prediabetes/diabetes. The circulating sphingolipidome is differentially regulated in humans according to sex, glucose, and BMI.

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Morano et al. (2026) studied this question.

synapsesocial.com/papers/6a8aa6bde0083a7c2c438b75 https://doi.org/10.1152/ajpendo.00049.2026

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The interaction between glucose levels and body mass index on the regulation of the circulating sphingolipidome in humans

Key Points

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Implication

Abstract

Discussion

Cite This Study

The interaction between glucose levels and body mass index on the regulation of the circulating sphingolipidome in humans

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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