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January 1, 2025Journal of Food Science

Fecal fatty acid profile reveals the therapeutic effect of red ginseng acidic polysaccharide on type 2 diabetes mellitus in rats

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Why the study?

The study was conducted to investigate the potential hypoglycemic mechanism of red ginseng acidic polysaccharides from the perspective of fatty acid regulation.

Does red ginseng acidic polysaccharide improve hyperglycemia and regulate fecal fatty acid profiles in T2DM rat models?

Population

Type 2 diabetes mellitus rat models

Comparison

Red ginseng acidic polysaccharides treatment vs untreated T2DM rat models

Design

Preclinical animal study

Authors

JYJingxuan YangYWYi WuZJZiye Jiang

Discussion

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Overview

Hypothesis-generating for RGAP in T2DM; human trials required before any clinical consideration.

Structured PICO

Does red ginseng acidic polysaccharide improve hyperglycemia and regulate fecal fatty acid profiles in T2DM rat models?

P
Population
Type 2 diabetes mellitus (T2DM) rat models established by high-glucose/high-fat diet and streptozotocin administration
I
Intervention
Red ginseng acidic polysaccharides (RGAP)
C
Comparator
Untreated T2DM rat models
O
Outcome
Fecal fatty acid profile and fasting blood glucose levelssurrogate

RGAP alleviates T2DM symptoms and hyperglycemia in rats, potentially through the regulation of fatty acid metabolism and inflammation-related signaling pathways.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/6a8aa7598b2cdb42c43323c9https://doi.org/10.1111/1750-3841.70015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anti-hyperlipidemic Effects of Red Ginseng Acidic Polysaccharide from Korean Red Ginseng2010 · 94 citations
  2. 2Korean Red Ginseng Extract Powder Mitigates Fasting And Postprandial Hyperglycemia in Type 2 Diabetic Mice2024
  3. 3Studies on Bioactive Components of Red Ginseng by UHPLC-MS and Its Effect on Lipid Metabolism of Type 2 Diabetes Mellitus2022 · 12 citations
  4. 4Fermented Red Ginseng Potentiates Improvement of Metabolic Dysfunction in Metabolic Syndrome Rat Models2016 · 36 citations
  5. 5Supplementation of Non-Fermented and Fermented Red Ginseng Improves Obese Phenotypes, Lipid and Inflammatory Profiles, and Antioxidant Defense System in High Fat-Fed Rats2021 · 2 citations