Preclinical study demonstrates synergistic metabolic disruption and apoptosis in lung cancer cells, indicating the therapeutic potential of dual metabolic inhibition.
. Furthermore, combining these two metabolic inhibitors could induce the production of ROS, reduce the generation of ATP, impair mitochondrial morphology and function, and ultimately activate apoptosis in tumor cells through metabolic regulation, facilitating antitumor treatment. The findings underscore the necessity and effectiveness of targeting tumor energy metabolism for lung cancer therapy, providing reliable evidence that metabolic therapies can effectively participate in cancer treatment.
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Bai et al. (2026) studied this question.
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