Research progress on biomarkers of blast lung injury: Transition from traditional indicators to novel molecular markers

Q: What does this research mean for the field?

The evolution of biomarkers for blast lung injury from conventional inflammatory indicators to novel molecular markers, combined with imaging and multi-omics, offers improved diagnostic accuracy and targeted therapies. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Hong Wang; Nan Yang; Liang Li; Xiaolin Fan; Yuhao Zhang; Ning Ma; Xiao Li; Boya Yu; Jinxuan Ma; Qing Lu; Junhong Gao

doi:10.1016/j.isci.2026.117197

August 20, 2026iScienceOpen Access

Research progress on biomarkers of blast lung injury: Transition from traditional indicators to novel molecular markers

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Key Points

To summarize the transition from conventional inflammatory indicators to novel molecular biomarkers in blast lung injury and outline their diagnostic and therapeutic applications.
Conducted a comprehensive review of literature on biological indicators associated with blast lung injury.
Evaluated biomarker roles across cell injury, inflammation, oxidative stress, epigenetic regulation, and multi-omics integration alongside imaging.
Identified a clear progression from non-specific inflammatory markers toward precise molecular indicators reflecting cellular damage, oxidative pathways, and epigenetic shifts.
Highlighted the diagnostic promise of integrating multi-omics technologies with clinical imaging while addressing ongoing translational obstacles in blast trauma management.

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Implication

Systematic review demonstrates the evolution of molecular and multi-omics biomarkers in blast lung injury, highlighting opportunities for improved early diagnosis and targeted therapy.

Abstract

Blast lung injury (BLI) poses great challenges for early diagnosis and precise treatment. This review systematically summarizes the evolution of relevant biomarkers from conventional inflammatory indicators to newly identified molecular markers related to cell injury, inflammation, oxidative stress, and epigenetic regulation. It also discusses imaging combination strategies, multi-omics applications, current translational obstacles, and future research trends. This work provides valuable theoretical references for improving diagnostic accuracy, optimizing prognostic evaluation, and developing targeted therapies for BLI.

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Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad667677a34114445872 https://doi.org/10.1016/j.isci.2026.117197

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Research progress on biomarkers of blast lung injury: Transition from traditional indicators to novel molecular markers

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Research progress on biomarkers of blast lung injury: Transition from traditional indicators to novel molecular markers

Key Points

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Implication

Abstract

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