Recurrence of autoimmune liver diseases after liver transplantation: exploratory analysis of a pooled Latin American cohort

Diana Lorena Sánchez Monroy

doi:10.48713/10336_48360

August 20, 2026Open Access

Recurrence of autoimmune liver diseases after liver transplantation: exploratory analysis of a pooled Latin American cohort

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Key Points

To describe the recurrence patterns of autoimmune liver diseases following liver transplantation and examine factors associated with recurrence, overall survival, and retransplantation.
Retrospective analytical cohort study of adult patients (N=154) with autoimmune liver disease who underwent liver transplantation between 2005 and 2023.
Recurrence was established using biochemical, serological, and histological criteria.
Outcomes and predictive variables were evaluated using logistic regression models, Fisher's exact tests, and Kaplan-Meier survival analyses.
Disease recurrence occurred in 64 of 154 patients (41.5%) after a median follow-up duration of 49 months (IQR 21.2–91).
Elevated pre-transplant AST demonstrated the most consistent independent association with recurrence across primary, adjusted, and sensitivity analyses, alongside elevated ALT and acute rejection in initial models.
No statistically significant differences were observed in overall survival rates or retransplantation requirements between patients with and without disease recurrence.

Implication

Cohort study finds post-transplant disease recurrence in 41.5% of autoimmune liver disease recipients, indicating high recurrence risk without immediate survival detriment.

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Cite This Study

Diana Lorena Sánchez Monroy (2026) studied this question.

synapsesocial.com/papers/6a8aad667677a34114445905 https://doi.org/10.48713/10336_48360

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Recurrence of autoimmune liver diseases after liver transplantation: exploratory analysis of a pooled Latin American cohort

Key Points

Implication

Discussion

Cite This Study

Recurrence of autoimmune liver diseases after liver transplantation: exploratory analysis of a pooled Latin American cohort

Key Points

Implication

Discussion

Cite This Study

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