What does this research mean for the field?

Epigenetically driven overexpression of PAPSS2 promotes gastric cancer progression by driving cell proliferation, migration, VEGFA-dependent angiogenesis, and M2 macrophage polarization. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the biological function, prognostic value, and epigenetic mechanisms regulating PAPSS2 expression in gastric cancer.

August 23, 2026HereditasOpen Access

Epigenetic upregulation of PAPSS2 drives proliferation, migration, angiogenesis, and M2 macrophage infiltration in gastric cancer

View Full Paper

Ask AI

Bookmark

Authors

YWYi WuNorth Sichuan Medical University WHWeiwei HeAffiliated Hospital of North Sichuan Medical College FLF. LiNorth Sichuan Medical University

Discussion

Member takes

Implication

In vitro and bioinformatic analysis reveals that epigenetically upregulated PAPSS2 promotes gastric cancer progression and angiogenesis, highlighting its potential as a therapeutic target.

Key Points

To investigate the biological function, prognostic value, and epigenetic mechanisms regulating PAPSS2 expression in gastric cancer.
Analyzed public multi-omics datasets to examine PAPSS2 expression, patient survival outcomes, immune cell infiltration, DNA methylation, and histone acetylation.
Evaluated oncogenic behavior and molecular mechanisms using qRT-PCR, western blotting, CCK-8 proliferation assays, Transwell migration/invasion assays, HUVEC tube formation, and ChIP assays.
PAPSS2 is significantly upregulated in gastric cancer tissues and cell lines, with elevated expression correlating with poorer patient overall survival.
Knockdown of PAPSS2 suppresses gastric cancer cell proliferation, migration, invasion, VEGFA-driven angiogenesis, and M2 macrophage polarization.
Promoter hypomethylation and p300/CBP-mediated H3K27 acetylation epigenetically drive PAPSS2 overexpression in gastric cancer cells.

Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a8aad977677a34114445cc0 https://doi.org/10.1186/s41065-026-00733-3

View Full Paper

Ask AI

Bookmark

Implication

In vitro and bioinformatic analysis reveals that epigenetically upregulated PAPSS2 promotes gastric cancer progression and angiogenesis, highlighting its potential as a therapeutic target.

Epigenetic upregulation of PAPSS2 drives proliferation, migration, angiogenesis, and M2 macrophage infiltration in gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Epigenetic upregulation of PAPSS2 drives proliferation, migration, angiogenesis, and M2 macrophage infiltration in gastric cancer

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider