Answers are grounded in this paper and cite their sources.
Preclinical study demonstrates enhanced bone regeneration and real-time healing tracking using a self-electrified 3D-printed device in rodents, highlighting an intelligent repair platform.
Critical-sized bone defects pose substantial clinical challenges, requiring both regenerative and diagnostic strategies for effective treatment. Here, we report a biodegradable, multifunctional cranial device based on three-dimensional printing. The device integrates a self-electrified scaffold based on a transient zinc-molybdenum battery and an impedance sensor for simultaneous electrical stimulation and continuous assessment of bone healing. The beneficial effects of electrical cues are attributed to elevated calcium ion influx, reactive oxygen species signaling, and up-regulated osteogenesis-related genes. In a rodent cranial defect model, the device promotes osteogenesis while enabling dynamic tracking of early tissue regeneration through impedance measurements. The increase in impedance is associated with enhanced collagen deposition and matrix mineralization. By uniting therapeutic stimulation with in situ monitoring, this work offers a platform for intelligent bone repair with broad potential in regenerative medicine.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: