Key result
DPE with standby ECMO maintains hemodynamic stability during cesarean delivery in severe rheumatic mitral stenosis.
Why the study?
Critical rheumatic mitral stenosis with pulmonary hypertension and right ventricular dysfunction in pregnancy is classified as mWHO Class IV with high maternal mortality, presenting major anesthetic challenges during the peripartum period.
Does a multidisciplinary anesthetic strategy including DPE and standby ECMO improve outcomes in pregnant patients with severe rheumatic mitral stenosis undergoing emergent cesarean delivery?
Case Report (n=1)
No
Does a multidisciplinary anesthetic strategy including DPE and standby ECMO improve outcomes in pregnant patients with severe rheumatic mitral stenosis undergoing emergent cesarean delivery?
This case demonstrates that favorable maternal outcomes can be achieved in mWHO Class IV cardiac disease with multidisciplinary planning and an anesthetic strategy prioritizing hemodynamics.
May support dural puncture epidural with standby ECMO in mWHO IV mitral stenosis; leaves open prospective validation before broader adoption.
Critical rheumatic mitral stenosis complicated by pulmonary hypertension and right ventricular dysfunction during pregnancy represents one of the most challenging scenarios in obstetric anesthesia. These patients are classified as modified World Health Organization (mWHO) Class IV, which is the highest maternal risk category with high maternal mortality rates. The peripartum period is especially dangerous since even modest hemodynamic shifts can trigger cardiovascular collapse. We report a successful case of anesthetic management of a 40-year-old gravida 3, para 2 at 29 weeks and three days gestation with severe rheumatic mitral stenosis, moderate-to-severe pulmonary hypertension, moderate-to-severe tricuspid regurgitation, and severely reduced right ventricular function. She was classified as New York Heart Association (NYHA) Class III, mWHO Class IV, and American College of Cardiology/American Heart Association (ACC/AHA) Stage C heart failure. She presented with worsening dyspnea and fetal decelerations after admission for decompensated heart failure and then underwent emergent cesarean section delivery, classified as category 2, with bilateral salpingectomy for permanent sterilization at the patient’s request. The anesthetic plan centered on three major strategies: a dural puncture epidural (DPE) with incremental dosing to allow gradual sympathectomy, invasive hemodynamic monitoring with early vasopressor support to preserve systemic vascular resistance (SVR), and prophylactic femoral arterial and venous sheath placement to allow rapid escalation to venoarterial (VA) extracorporeal membrane oxygenation (ECMO) if needed. Fortunately, the patient was hemodynamically stable throughout the procedure, did not require mechanical circulatory support, and was discharged in stable condition on postoperative day 10. This case demonstrates that favorable maternal outcomes can be achieved in patients with mWHO Class IV cardiac disease with meticulous multidisciplinary planning and an anesthetic strategy that prioritizes hemodynamics.
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Ghodasara et al. (2026) conducted a case report in Severe rheumatic mitral stenosis and cardiopulmonary complications in pregnancy (n=1). Dural puncture epidural (DPE) and standby ECMO was evaluated on Maternal and fetal survival and hemodynamic stability. Dural puncture epidural with standby extracorporeal membrane oxygenation maintained hemodynamic stability and resulted in favorable maternal and fetal outcomes in a pregnant patient with severe rheumatic mitral stenosis.
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