What does this research mean for the field?

Effective management of hidradenitis suppurativa requires early, personalized, and interdisciplinary care utilizing a multifaceted approach of systemic antibiotics, retinoids, and targeted immunomodulatory biologics. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the current evidence on systemic therapies, including conventional antibiotics, retinoids, and targeted biologic agents, for the treatment of hidradenitis suppurativa.

August 23, 2026Dermatologica SinicaOpen Access

Systemic treatment for hidradenitis suppurativa: A narrative review of current evidence

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Authors

CTC. C. TsaiCathay General Hospital YLYang LoFu Jen Catholic University

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Implication

Narrative review summarizes systemic therapeutic options for hidradenitis suppurativa, highlighting the expanding role of biologic and targeted immunomodulatory agents.

Key Points

To review the current evidence on systemic therapies, including conventional antibiotics, retinoids, and targeted biologic agents, for the treatment of hidradenitis suppurativa.
Narrative synthesis of clinical evidence evaluating systemic agents for hidradenitis suppurativa.
Assessed first-line antibiotics, retinoids, approved biologic agents, and emerging investigational small molecules.
Oral tetracyclines and clindamycin-rifampicin provide first-line benefit, while acitretin benefits select phenotypes, though both strategies face challenges with relapse, resistance, or toxicity.
Adalimumab shows improved outcomes when initiated early, used continuously, or combined with surgery, and infliximab provides efficacy in severe refractory cases despite immunogenicity.
Interleukin-17 inhibitors (secukinumab and bimekizumab) demonstrate high and durable response rates, with interleukin-1 and Janus kinase inhibitors showing promising investigational utility.

Cite This Study

Tsai et al. (2026) studied this question.

synapsesocial.com/papers/6a8aadd57677a34114446476 https://doi.org/10.4103/ds.ds-d-25-00180

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Implication

Narrative review summarizes systemic therapeutic options for hidradenitis suppurativa, highlighting the expanding role of biologic and targeted immunomodulatory agents.

Systemic treatment for hidradenitis suppurativa: A narrative review of current evidence

Discussion

Member takes

Implication

Key Points

Cite This Study

Systemic treatment for hidradenitis suppurativa: A narrative review of current evidence

Discussion

Member takes

Implication

Key Points

Cite This Study

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